Per1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comPer1 ELISA Kit for Rat(Rattus norvegicus)

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Per1 (Gene name),

Period circadian protein homolog 1 (Protein name ), PER1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Per1;

Protein name:

Period circadian protein homolog 1(rPER1);

Alternative:

Circadian clock protein PERIOD 1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with TIMELESS, PER2, PER3 and, through a C-terminal domain, with CRY1 and CRY2. Interaction with CSNK1D or CSNK1E promotes nuclear location of PER proteins. Interacts with GPRASP1.

Function:

Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation.

Subcellular Location:

Nucleus Cytoplasm Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER1 nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2.

Protein Attributes:

Sequence length:

1293

Sequence:

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1250:

1293:

GGEEAQTQIG | TKGSSSQDSA | MEEEEQGGSS | SSPALPAEEN | GTS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:287422

Pfam:

PF08447

UniGene:

Rn.34433

String:

Q8CHI5

Pfam:

PF12114

Uniprot:

Q8CHI5

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ELISA Kit for Rat rPER1

Cat.:

E3144h

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96T

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ELISA Kit for Rat rPER1

Cat.:

E3144m

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MSDS:

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Packing:

96T

ELISA Kit for Rat rPER1

Cat.:

E3144r

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96T

CLIA Kit for Rat rPER1

Cat.:

U3144r

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Packing:

96T

CLIA Kit for Rat rPER1

Cat.:

U3144h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat rPER1

Cat.:

U3144m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat rPER1

Cat.:

P3144Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat rPER1

Cat.:

P3144Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat rPER1

Cat.:

P3144Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat rPER1

Protein for Rat rPER1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Positional cloning of rat hd."
Liska F. , Blachut S. , Gosele C. , Kren V. , Krenova D. , Hubner N.
Submitted (2005-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: BN-Lx/Cub.
strain: SHR/OlaIpcv.
strain: Wistar Hd.
tissue: Testis.
2.

Suzuki S. , Oishi K. , Sakamoto K. , Ishida N.
Submitted (2002-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1244
tissue: Brain.
3.

"Distribution of the rhythm-related genes rPERIOD1, rPERIOD2, and rCLOCK, in the rat brain."
Shieh K.-R.
Neuroscience118:831-843(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
4.

"A novel protein interacts with a clock-related protein, rPer1."
Matsuki T. , Kiyama A. , Kawabuchi M. , Okada M. , Nagai K.
Brain Res.916:1-10(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GPRASP1
5.

"Indication of circadian oscillations in the rat pancreas."
Muehlbauer E. , Wolgast S. , Finckh U. , Peschke D. , Peschke E.
FEBS Lett.564:91-96(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
6.

"PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator."
Brown S.A. , Ripperger J. , Kadener S. , Fleury-Olela F. , Vilbois F. , Rosbash M. , Schibler U.
Science308:693-696(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NONO AND WDR5
7.

"Clock gene Per1 regulates the production of CCL2 and interleukin-6 through p38, JNK1 and NF-kappaB activation in spinal astrocytes."
Sugimoto T. , Morioka N. , Zhang F.F. , Sato K. , Abe H. , Hisaoka-Nakashima K. , Nakata Y.
Mol. Cell. Neurosci.59C:37-46(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INFLAMMATION;TISSUE SPECIFICITY

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